Fig. 7
From: Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy
ADan oligomers do not alter the number and localization of synaptic proteins in Tau−/− mice derived cerebellar granule neurons. a Representative immunofluorescence photographs for clusters of the synaptic proteins Synapsin-1 (red), PSD95 (green), and their colocalization (yellow) in cerebellar granule neuronal dendrites. Four experimental groups were analyzed: WT and Tau−/− neurons in the presence or absence of ADan oligomers (+ADan, b-d) Graphs showing the quantification of positive ((+)) clusters for each marker and their colocalization per 100 μm of dendrite. The number of cells analyzed was 15 per each culture, from 3 independent cultures. Results are shown as the mean ± SEM of n = 3. Asterisks indicate significant differences, where * p < 0.05 and *** p < 0.001 by Mann-Whitney test. Scale bar = 10 μm