Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

Fig. 2

Chronic MLi-2 administration results in dramatic LRRK2 inhibition peripherally and in the central nervous system of mice. a Western blot images from liver lysate of animals treated with control or MLi-2 diet and assayed for total LRRK2, pS935 LRRK2 and GAPDH levels. b Quantification of total LRRK2 and pS935 LRRK2 levels normalized to GAPDH as an internal control and the mean of all control diet-treated animals. LRRK2, p = 0.4891, t test with Welch’s correction; pS935 LRRK2; p < 0.0001, unpaired t test; pS935/total LRRK2, p < 0.0001, unpaired t test. c Western blot images from spinal cord lysate of animals treated with control or MLi-2 diet and assayed for total LRRK2, pS935 LRRK2 and GAPDH levels. d Quantification of total LRRK2 and pS935 LRRK2 levels normalized to GAPDH as an internal control and the mean of all control diet-treated animals. LRRK2, p = 0.0989, unpaired t test; pS935 LRRK2; p = 0.0011, unpaired t test; pS935/total LRRK2, p = 0.0008, unpaired t test. All plots are means and error bars represent s.e.m. with individual values plotted

Back to article page