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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

Fig. 7

a-c: Ubiquitin-positive intranuclear inclusions were unexpectedly found in neurons. Neuronal intranuclear inclusions are shown for the paraventricular nucleus (a) of the hypothalamus (arrowheads in a; brown DAB reaction product) and ventromedial hypothalamus (arrowheads in b). No inclusions were found in neurons in Gfa2-CGG11 control mice (c) or in WT mice. d-f: Immunohistofluorescent staining for ubiquitin-positive intranuclear inclusions (arrowhead) in neurons in Gfa2-CGG99 mice in the inferior olivary nucleus (d) and suprachiasmatic nucleus (e). f For comparison, these inclusions are similar to the inclusions found in neurons in the mammillary body of a CGG159 KI mouse. In Figs. d-f, ubiquitin is immunofluorescently labeled green (Alexa 488, arrowheads) and neurons identified by immunostaining red for NeuN (Alexa 468). Scale bars: a-c: 5 μm; A-F: 10 μm

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