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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

Fig. 5

Immunofluorescent labeling and ultrastructure of ubiquitin-positive intranuclear inclusions in neurons and astroglia of the CGG KI mouse. Ubiquitin-positive intranuclear inclusions (red) in a protoplasmic astroglia (green; arrow) and pyramidal neurons (arrow heads) in the neocortex of a CGG128 KI mouse. These fluorescently labeled intranuclear inclusions are shown for comparison with inclusions found in astrocytes in the Gfa2-CGG99 mouse brain. Ubiquitin was immunofluorescently labeled red, GFAP green, and nuclei stained blue using DAPI

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