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Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

Fig. 10

Double immunofluorescent staining reveals FMRpolyG positive inclusion bodies in both astrocytes (a) and neurons (b) from Gfa2-CGG99 mice. a. Photomicrograph showing FMRpolyG-positive inclusion bodies (red) located within GFAP positive astrocytes (green; arrow) as well as in a GFAP negative cell that is probably neuronal (arrow head). b. Photomicrograph showing FMRpolyG-positive inclusion bodies (red) located within a MAP 2 positive (green; arrow) neuron as well as in a MAP 2 negative cell that is probably an astrocyte (arrow head). c Representative brain section from a Gfa2-CGG99 mouse processed for immunofluorescence but without 8FM mouse anti-FMRpolyG primary antibody

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