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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

Fig. 1

a Diagram of DNA fragment used for pronuclear injection with either an 11CGG or 99CGG trinucleotide repeat expansion on exon 1. b Nucleotide sequence of DNA construct used to make the GFAP-CGG11-EGFP or GFAP-CGG99-EGFP transgenic mice. The sequence contained either an 11CGG or 99CGG trinucleotide repeat sequence for the two transgenic mouse lines that was located between the two arrows in b. The bracketed acg sequence upstream of the repeat sequence shows the alternative translation start site supporting repeat-associated non-ATG (RAN) translation as described in Sellier, et al., 2017

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Acta Neuropathologica Communications

ISSN: 2051-5960

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