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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke

Fig. 8

α5-PKO mice have less severe TJP loss after ischemic stroke. a Representative images of ZO-1 (green) and CD31 (red) staining in the penumbra of control and α5-PKO brains at days 1, 2 and 7 after injury. Scale bar = 50 μm. b Quantification showing higher ZO-1 coverage in the penumbra of α5-PKO brains at days 1 and 2 but not 7 after injury. n = 5. c Representative images of Claudin-5 (green) and CD31 (red) staining in the penumbra of control and α5-PKO brains at days 1, 2 and 7 after injury. Scale bar = 50 μm. d Quantification showing higher Claudin-5 coverage in the penumbra of α5-PKO brains at days 1 and 2 but not 7 after injury. n = 5. * p < 0.05, compared to controls at the same time points

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