Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

Table 7 Spearman correlations between demographic, cognitive, or global neuropathological measures and tau markers in local axonal and somatodendritic compartments of the CA3-Schaffer collateral pathway

Region	Tau Marker	Age	Braak Stage	Global CERADPlaque Density	Global Tangle Density	NIA-Reagan Score
CA3 Pyramidal Cell Density	AT8	r = 0.344 p = 0.032	r = 0.462* p = 0.003	r = 0.241 p = 0.139	r = 0.441* p = 0.005	r = 0.508* p = 0.001
CA3 Pyramidal Cell Density	TNT2	r = 0.227 p = 0.165	r = 0.213 p = 0.193	r = −0.062 p = 0.979	r = 0.322 p = 0.046	r = 0.135 p = 0.412
Schaffer Collateral Fiber Density	AT8	r = 0.521* p = 0.0003	r = 0.524* p = 0.0003	r = 0.109 p = 0.481	r = 0.533* p = 0.0002	r = 0.456* p = 0.002
Schaffer Collateral Fiber Density	TNT2	r = 0.305 p = 0.044	r = 0.497* p = 0.0006	r = 0.331 p = 0.028	r = 0.522* p = 0.0003	r = 0.567* p = 0.0006

PMI post-mortem interval, MMSE mini mental state exam, NIA-Reagan National Institute on Aging-Reagan Institute AD probability level, CA cornu ammonis, DG dentate gyrus, Braak stages ranged from 1 to 3. * indicates a significant correlation (p ≤ 0.005, adjusted p-value for multiple comparisons)

ISSN: 2051-5960