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Table 7 Spearman correlations between demographic, cognitive, or global neuropathological measures and tau markers in local axonal and somatodendritic compartments of the CA3-Schaffer collateral pathway

From: Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

Region Tau Marker Age Braak Stage Global CERADPlaque Density Global Tangle Density NIA-Reagan Score
CA3 Pyramidal Cell Density AT8 r = 0.344
p = 0.032
r = 0.462*
p  = 0.003
r = 0.241
p = 0.139
r = 0.441*
p = 0.005
r = 0.508*
p  = 0.001
TNT2 r = 0.227
p = 0.165
r = 0.213
p = 0.193
r = −0.062
p = 0.979
r = 0.322
p = 0.046
r = 0.135
p = 0.412
Schaffer Collateral Fiber Density AT8 r = 0.521*
p  = 0.0003
r = 0.524*
p = 0.0003
r = 0.109
p = 0.481
r = 0.533*
p = 0.0002
r = 0.456*
p  = 0.002
TNT2 r = 0.305
p = 0.044
r = 0.497*
p = 0.0006
r = 0.331
p = 0.028
r = 0.522*
p  = 0.0003
r = 0.567*
p  = 0.0006
  1. PMI post-mortem interval, MMSE mini mental state exam, NIA-Reagan National Institute on Aging-Reagan Institute AD probability level, CA cornu ammonis, DG dentate gyrus, Braak stages ranged from 1 to 3. * indicates a significant correlation (p ≤ 0.005, adjusted p-value for multiple comparisons)