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Table 4 Spearman correlations between demographic, cognitive, or global neuropathological measures and tau markers in local axonal and somatodendritic compartments of the DG-mossy fiber pathway

From: Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

Region Tau Marker Age Braak Stage Global CERADPlaque
Density
Global Tangle Density NIA-Reagan
Score
DG Granule Cell
Density
AT8 r = 0.299
p = 0.058
r = 0.472*
p = 0.002
r = 0.069
p = 0.670
r = 0.504*
p = 0.0008
r = 0.394
p = 0.01
TNT2 r = 0.255
p = 0.113
r = 0.280
p = 0.080
r = 0.004
p = 0.702
r = 0.239
p = 0.137
r = 0.253
p = 0.116
Mossy Fiber Density AT8 r = 0.446*
p = 0.004
r = 0.337
p = 0.036
r = 0.205
p = 0.211
r = 0.418
p = 0.008
r = 0.470*
p = 0.003
TNT2 r = 0.477*
p = 0.002
r = 0.484*
p = 0.002
r = 0.156
p = 0.344
r = 0.539*
p = 0.0004
r = 0.420
p = 0.008
  1. PMI post-mortem interval, MMSE mini mental state exam, NIA-Reagan National Institute on Aging-Reagan Institute AD probability level, CA cornu ammonis, DG dentate gyrus; Braak stages ranged from 1 to 3. * indicates a significant correlation (p ≤ 0.005, adjusted p-value for multiple comparisons)