Skip to main content

Table 1 Demographic, clinical, and neuropathological characteristics by diagnosis

From: Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

  Clinical diagnosis   Comparison by diagnosis group
  ND MCI Total (P value)
(N = 31) (N = 13) (N = 44)  
Age at death (years)
 Mean ± SD 83.1 ± 6.1 86.2 ± 5.4 84.0 ± 6.0 0.13#
 (Range) (69–97) (74–95) (69–97)  
Sex 19 M/12F
(61.3% Male)
8 M/5F
(61.5% Male)
27 M/17F (61.4% Male) > 0.99
Postmortem Interval (hours)
 Mean ± SD 2.7 ± 0.6 2.7 ± 0.5 2.7 ± 0.6 0.84#
 (Range) (1.5–4.8) (1.8–3.5) (1.5–4.8)  
MMSE
 Mean ± SD 28.5 ± 1.3 27.4 ± 2.4 28.2 ± 1.7 0.34#
 (Range) (26–30) (23–30) (23–30)  
 No Score (N) 8 4 12  
Braak Stage
 I 5 3 8 0.85§
 II 7 3 10
 III 19 7 26
NIA-Reagan AD Probability Level
 Not AD (0) 9 4 13 0.87§
 Low (1) 7 2 9
 Intermediate (2) 15 7 22
 High (3) 0 0 0
Global CERAD Plaque Density
 None (0) 9 4 13^ 0.96§
 Sparse (1) 7 3 10$
 Moderate (2) 8 4 12$
 Frequent (3) 7 2 9$
  1. ND non-demented, MCI mild cognitive impairment, MMSE Mini-Mental State Examination, NIA-Reagan National Institute on Aging-Reagan Institute AD probability level, CERAD Consortium to Establish a Registry for Alzheimer’s disease, AD Alzheimer’s disease. ^primary age-related tauopathy (PART) cases; $non-PART cases; #Mann-Whitney test; Fisher’s exact test; §Chi-square test