Fig. 9

Non-PART cases contained greater levels of AT8+ and TNT2+ neurites and neurons in the DG-mossy fiber and CA3-Schaffer collateral pathways. (a-b) AT8+ neurons (a; p < 0.0001) and neurites (b; p = 0.0117) were significantly increased in non-PART cases compared to PART cases in the DG-mossy fiber pathway. (c-d) In the CA3-Schaffer collateral pathway, AT8+ neurons (c; p = 0.0024) and neurites (d; p = 0.0315) were significantly increased in non-PART cases compared to PART cases. (e-f) TNT2+ mossy neurites (f; p = 0.0175) were significantly increased in non-PART cases compared to PART cases, but not TNT2+ DG neurons (e; p = 0.0626) in the DG-mossy fiber pathway. (g-h) In the CA3-Schaffer collateral pathway, TNT2+ neurites (h; p = 0.0011) were significantly increased in non-PART cases compared to PART cases, but not TNT2+ CA3 neurons (g; p = 0.4232). All comparisons made using Mann-Whitney U-test, the data are median with interquartile range, and split y-axis were used with some data sets to better illustrate data spread