Fig. 7

Age-dependence of FTLD-like pathogenesis of TDP-43 cKO mice. The ages (months) of the detection of different behaviour (blue), cellular, and molecular pathologies in TDP-43 cKO mice upon conditional depletion of TDP-43 in their forebrain neurons are indicated along the time line on the top. Also listed in the 2 lower boxes are mis-regulated genes associated with specific pathogenic event, e.g. Gfap/ Serpina3a/ C4a/ C4b/ A2m and astrocyte activation, etc., are identified by RNA-Seq analysis of the TDP-43 cKO mouse neocortex on 3 and 12 months (genes altered in FTLD patients are indicated by red color), respectively. For more details, see text