Fig. 6

RNA-Seq analysis of circRNAs. a Upper panel, list of the numbers of cirRNAs in the neocortex of 3 each of TDP-43 cKO and Ctrl mice at the ages of 3 months and 12 months, respectively. Lower plot, venn diagram showing the numbers of cortex circRNAs the expression levels of which were different between the TDP-43 cKO and Ctrl mice at the ages of 3 months and 12 months, respectively. Note that the levels of 22 cricRNAs were changed at both ages. b Upper panels, scatter plot showing the correlation of log₂ fold change (FC, TDP-43 cKO/Ctrl) of cortex circRNAs (x axis) and their cognate linear mRNAs (y axis) the levels of which were altered in TDP-43 cKO mice only at the age of 3 months or only at the age of 12 months in comparison to Ctrls. Lower panels, scatter plot showing the correlation of log₂ FC of neocortex circRNAs (x axis) and their cognate linear RNAs (y axis) the levels of which were changed at both the ages of 3 months and 12 months in TDP-43 cKO mice in comparison to Ctrls. Blue circles indicate changes of the expression levels of only the circRNAs, while green squares indicate changes of the expression levels of both the circRNAs and their cognate mRNAs counterparts