Neuronal loss/gliosis | Aβ deposits/CWPs | NFTs | Lewy bodies/Lewy neurites | TDP-43 positive NCIs/short neurites | |
---|---|---|---|---|---|
Primary motor cortex | +++ | +++++/+++ | ++++ | −/− | −/− |
Superior frontal gyrus | +++ | +++++/+++++ | ++++ | −/− | −/− |
Middle frontal gyrus | +++ | +++++/++++ | ++++ | −/− | −/− |
Inferior frontal gyrus | +++ | +++++/++++ | ++++ | −/− | −/− |
Frontal white matter | +++ | ++/− | – | −/− | −/− |
Superior temporal gyrus | +++ | +++++/+++++ | ++++ | −/− | −/− |
Middle temporal gyrus | +++ | +++++/+++++ | ++++ | −/− | −/− |
Inferior temporal gyrus | +++ | +++++/+++++ | ++++ | ++/++ | +/+ |
Lateral occipitotemporal gyrus | +++ | +++++/+++++ | ++++ | +/++ | ++/+ |
Temporal white matter | +++ | ++++/− | – | −/− | −/− |
Parietal cortex | +++ | +++++/++++ | ++++ | −/− | −/− |
Parietal white matter | +++ | ++++/− | – | −/− | −/− |
Occipital cortex | +++ | ++++/+++ | ++++ | −/− | −/− |
Occipital white matter | +++ | ++++/− | – | −/− | −/− |
Entorhinal cortex | +++ | +++++/++++ | ++++ | +++/++++ | ++++/− |
Hippocampal CA1 | +++ | +++++/++++ | ++++ | +/− | ++++/− |
Amygdala | + | +++++/++++ | +++++ | ++++/++++ | ++++/++ |
Caudate nucleus | +++ | +++++/+++++ | ++++ | −/− | −/− |
Putamen | +++ | +++++/+++++ | +++++ | −/− | −/− |
Globus pallidus | +++ | ++/− | ++++ | −/− | −/− |
Subthalamic nucleus | n.a. | n.a. | n.a. | n.a. | n.a. |
Oculomotor nucleus | – | −/− | ++ | −/− | −/− |
Substantia nigra | +++ | +/− | ++++ | −/+ | −/− |
Frontopontine tract | – | +/− | – | −/− | −/− |
Corticospinal tract | |||||
at level of cerebral peduncle | +++ | −/− | – | −/− | −/− |
at level of pons | +++ | −/− | – | −/− | −/− |
at level of medulla oblongata | +++ | −/− | – | −/− | −/− |
Locus coeruleus | ++ | +/− | ++ | +/− | −/− |
Pontine nucleus | – | ++/− | +++ | −/− | −/− |
Superior cerebellar peduncle | – | −/− | – | −/− | −/− |
Transverse pontine fibers | – | −/− | – | −/− | −/− |
Dorsal vagal nucleus | + | +/− | ++ | −/− | −/− |
Hypoglossal nucleus | – | +/− | – | −/− | −/− |
Inferior olivary nucleus | – | +/+ | – | −/− | −/− |
Cerebellum | |||||
Molecular layer | + | ++++/− | – | −/− | −/− |
Purkinje cell layer | – | ++/− | – | −/− | −/− |
Granular layer | – | ++++/− | – | −/− | −/− |
Dentate nucleus | – | +++++/− | +++ | −/− | −/− |
White matter | ++ | +/− | – | −/− | −/− |
Spinal cord | |||||
Anterior horn | – | ++/− | – | −/− | −/− |
Corticospinal tract | +++ | +/− | – | −/− | −/− |