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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation

Fig. 7

Absence of congophilia of CWPs with glial proliferation. a, b Cotton wool plaques (CWPs) on section stained with Congo red. Observation with polarized light demonstrates apple green birefringence in the amyloid angiopathy but not CWPs (b). The insular cortex. c, d GFAP-positive astrocytes (c) and Iba1-positive microglias (d) surrounding CWPs. The inferior temporal gyrus. All scale bars = 50 μm

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