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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation

Fig. 5

Aβ42 and Aβ40 immunohistochemistry on serial sections from the temporal cortex and cerebellar cortex. a, b Serial sections from the inferior temporal cortex. Aβ42 (a) rather than Aβ40 (b) is predominantly accumulated in CWPs as well as cerebral amyloid angiopathy. c, d Serial sections from the cerebellar cortex. Aβ42 (c) rather than Aβ40 (d) is predominantly accumulated in the cerebellar cortex, while both are almost equally accumulated in cerebral amyloid angiopathy. Scale bars = a, b 100 μm, c, d 30 μm

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