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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation

Fig. 4

Histopathological findings of the present case. a, b Numerous eosinophilic, round, non-cored, and large cotton wool plaques in the insula cortex. The diameter of the plaques is often 100 μm or over. The rarefaction in the neuropil is also remarkable. Hematoxylin-eosin stain. c Aβ-positive abundant CWPs in all cortical layers. The inferior frontal gyrus. 12B2 immunohistochemistry. d A CWP showing a mass effect on around myelinated fibers in the neuropil. The inferior frontal gyrus. Klüver-Barrera stain. e Modified Bielschowsky silver stain showed heterogeneous argyrophilia but no clear amyloid core in a CWP. The middle frontal gyrus. f Gallyas silver stain shows only weak argyrophilia of homogeneous material composing a CWP. The inferior frontal gyrus. g A CWP strongly stained with an anti-Aβ antibody. The inferior frontal gyrus. 12B2 immunohistochemistry. h Aβ deposits in the dentate nucleus in the cerebellum. 12B2 immunohistochemistry. Scale bars = a 100 μm, b 30 μm, c 100 μm, d, e, f, g 30 μm, h 40 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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