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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation

Fig. 3

Macroscopic findings of the present case. a Lateral view of the left hemisphere. Severe diffuse atrophy including the precentral gyrus (an asterisk) is seen. b On a coronal section, severe atrophy is evident in the cortex and white matter of the frontal and temporal lobes. The basal ganglia also show severe atrophy. The width of the corpus callosum is severely reduced. c Remarkable atrophy of the hippocampus and parahippocampal gyrus. d Severe depigmentation in the substantia nigra. e Depigmentation in the locus coeruleus. f Severe atrophy in the pyramidal tract at the level of the medulla oblongata

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