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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

Fig. 9

Emergence of a deficit in synaptic plasticity in CA3-CA1 synapses. a TBS-induced LTP (arrowhead) was similar between control and APP/tTA mice reared on dox (always-on-dox). b End LTP value, averaged 50–60 min after TBS, showed that APP/tTA mice reared on dox exhibited a similar level of LTP to control littermates (control mean = 168.1 ± 11.74, n = 6; APP/tTA mean = 152.1 ± 8.34, n = 6). Example traces are shown for time points immediately before (thin line) and 60 min after (thick line) LTP induction. c TBS-induced LTP was normal in APP/tTA mice expressing APPSw,Ind for 2 weeks (2 weeks-off-dox). d APP/tTA mice expressing APPSw,Ind for 2 weeks exhibited a similar LTP response as control littermates (control mean = 141.2 ± 8.46, n = 6; APP/tTA mean = 159.0 ± 14.66, n = 6). e TBS-induced LTP was impaired in APP/tTA mice expressing APPSw,Ind for 3 weeks (3 weeks-off-dox). f End LTP response was lower in APP/tTA expressing APPSw,Ind for 3 weeks (control mean = 169.1 ± 9.09, n = 8; APP/tTA mean = 115.4 ± 9.69, n = 6). g TBS-induced LTP was impaired in APP/tTA mice expressing APPSw,Ind for 12 weeks (12 weeks-off-dox). h End LTP response was lower in APP/tTA expressing APPSw,Ind for 12 weeks (control mean = 156.5 ± 7.75, n = 9; APP/tTA mean = 118.0 ± 4.17, n = 9). i TBS-induced LTP was reduced in APP/tTA mice expressing APPSw,Ind for 29 weeks (29 weeks-off-dox). j End LTP response was lower in APP/tTA expressing APPSw,Ind for 29 weeks (control mean = 174.7 ± 15.06, n = 6; APP/tTA mean = 132.2 ± 8.24, n = 6). Labels in a apply to all LTP plots in figure. Scale bar calibration: 5 ms, 0.5 mV

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