Fig. 8
Emergence of a deficit in paired-pulse response in CA3-CA1 synapses. a Paired-pulse response was similar in APP/tTA and control mice reared on dox (control mean = 2.1 ± 0.13, n = 6; APP/tTA mean = 2.0 ± 0.18, n = 6). b Normal paired-pulse response in APP/tTA mice expressing APPSw,Ind transgene for 2 weeks (control mean = 2.0 ± 0.11, n = 7; APP/tTA mean = 2.0 ± 0.08, n = 7). c Normal paired-pulse response in APP/tTA mice expressing APPSw,Ind transgene for 3 weeks (control mean = 2.0 ± 0.06, n = 8; APP/tTA mean = 1.7 ± 0.12, n = 8). d Normal paired-pulse response in APP/tTA mice expressing APPSw,Ind for 12 weeks (control mean = 1.8 ± 0.07, n = 11; APP/tTA mean = 1.7 ± 0.07, n = 11). e Impaired paired-pulse response in APP/tTA mice expressing APPSw,Ind for 29 weeks (control mean = 1.9 ± 0.06, n = 6; APP/tTA mean = 1.6 ± 0.07, n = 6). Scale bar calibration: 10 ms, 0.2 mV