Fig. 6

Emergence of spatial reference memory deficit on the Y-water maze. a APP/tTA mice expressing APP_Sw,Ind for 2 weeks (2 weeks-off-dox) performed similarly to control littermates (control n = 6, APP/tTA n = 6). Dashed line represents chance level of performance of 50%. b Probe trial performed at the end of water maze training showed APP/tTA mice performed slightly, but not significantly, better than control littermates (control mean = 51.9 ± 2.81; APP/tTA mean = 63.4 ± 4.75). Dashed line represents chance level of performance of 33.3%. c Analysis of acquisition showed that APP/tTA mice expressing APP_Sw,Ind for 3 weeks (3 weeks-off-dox) performed similarly to control littermates (control n = 14, APP/tTA n = 9). d Probe trial showed that APP/tTA mice performed similar to control littermates (control mean = 47 ± 4.74; APP/tTA mean = 55.3 ± 2.87). e RM-ANOVA analysis of acquisition showed that APP/tTA mice expressing APP_Sw,Ind for 12 weeks (12 weeks-off-dox) showed an effect of genotype but no interaction between genotype and block (control n = 16, APP/tTA n = 13). f Probe trial results showed that APP/tTA mice expressing APP_Sw,Ind for 12 weeks spent a significantly lower percentage time within the goal arm compared to control littermates (control mean = 51.9 ± 3.38; APP/tTA mean = 42.2 ± 3.10)