Fig. 5
Mature-onset APP/tTA mice exhibit thigmotaxic behavior on the Morris water maze. a Analysis of latency to platform showed that APP/tTA mice reared on dox (always on dox) performed similar to control littermates (control n = 6, APP/tTA n = 6). b Probe trial performed at the end of water maze testing showed no significant difference in time spent within the target quadrant (control mean = 48.7 ± 6.72; APP/tTA mean = 55.4 ± 6.32). Dashed line represents chance level performance of 25%. c APP/tTA mice expressing APPSw,Ind for 2 weeks (2 weeks-off-dox) were slower to reach the platform compared to control littermates (control n = 6, APP/tTA n = 6). d Probe trial showed that APP/tTA mice expressing APPSw,Ind for 2 weeks spent a similar percentage of time in the platform quadrat as control littermates (control mean = 45 ± 9.82; APP/tTA mean = 41.2 ± 6.79). e Thigmotaxis analysis showed that APP/tTA mice expressing APPSw,Ind for 2 weeks were more thigmotaxic compared to control littermates