Fig. 4
Emergence of spatial working memory deficit on the T-maze. a APP/tTA mice reared on dox to suppress APPSw,Ind throughout life performed similar to control littermates (control mean = 79.1 ± 3.07, n = 17; APP/tTA mean = 82.2 ± 2.57, n = 17). Dashed line represents chance level performance of 50%. b Spontaneous alternation score was similar between APP/tTA mice expressing APPSw,Ind for 2 weeks (2 weeks-off-dox) and control littermates (control mean = 77.7 ± 3.06, n = 16; APP/tTA mean = 84.3 ± 2.34, n = 12). c A reduced spontaneous alternation score was observed in APP/tTA mice expressing APPSw,Ind for 3 weeks (3-weeks-off-dox; control mean = 85.1 ± 1.44, n = 14; APP/tTA mean = 77.3 ± 2.89, n = 14). d APP/tTA mice expressing APPSw,Ind for 12 weeks (12 weeks-off-dox) exhibited reduced alternation scores compared to control littermates (control mean = 84.1 ± 3.83, n = 8; APP/tTA mean = 67.5 ± 3.38, n = 11)