Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

Fig. 2

Developmental onset APP/tTA mice display impaired basal synaptic transmission but normal long term potentiation. a Input-output response was reduced in the CA3-CA1 pathway of developmental onset APP/tTA mice compared to control littermates (control n = 15, APP/tTA n = 15). Scale bar calibration: 5 ms, 0.5 mV. b Reduced paired-pulse response in developmental onset APP/tTA mice (control mean = 2 ± 0.05, n = 14; APP/tTA mean 1.8 ± 0.07, n = 14). Scale bar calibration: 10 ms, 0.2 mV. c TBS-induced LTP (arrowhead) was similar between developmental onset control and APP/tTA mice. d End LTP value, averaged 50–60 min after TBS, showed that APP/tTA mice exhibit a similar level of LTP to control littermates (control mean = 138.6 ± 11.2, n = 12; APP/tTA mean 145.6 ± 15.4, n = 12). fEPSP example traces shown for time points immediately before (thin line) and 60 min after (thick line) LTP induction. Scale bar calibration: 5 ms, 0.5 mV

Back to article page