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Table 1 KEGG pathway-Based gene set enrichment analyses (GSEA)

From: EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

Pathway Name NES NOM p-val FDR q-val
Nicotine addiction 2.41 < 0.001 < 0.001
Glutamatergic synapse 2.08 < 0.001 0.001
Morphine addiction 2.03 < 0.001 0.001
Retrograde endocannabinoid signaling 1.97 < 0.001 0.001
GABAergic synapse 1.87 < 0.001 0.005
Axon guidance 1.83 < 0.001 0.007
Circadian entrainment 1.78 < 0.001 0.010
Calcium signaling pathway 1.77 < 0.001 0.011
Cocaine addiction 1.73 0.004 0.015
Salivary secretion 1.56 0.002 0.070
Neuroactive ligand-receptor interaction 1.55 < 0.001 0.072
Parkinson’s disease 1.53 0.002 0.079
Dopaminergic synapse 1.51 0.005 0.082
Platelet activation − 1.50 0.003 0.048
Central carbon metabolism in cancer − 1.50 0.020 0.047
Choline metabolism in cancer −1.50 0.003 0.046
One carbon pool by folate −1.50 0.042 0.046
Hypertrophic cardiomyopathy (HCM) −1.51 0.012 0.043
TGF-beta signaling pathway −1.53 0.014 0.036
Prolactin signaling pathway −1.54 0.007 0.036
Inflammatory bowel disease (IBD) −1.55 0.018 0.031
DNA replication −1.55 0.026 0.031
NOD-like receptor signaling pathway −1.55 0.011 0.031
Colorectal cancer −1.55 0.009 0.031
Non-alcoholic fatty liver disease (NAFLD) −1.56 0.002 0.029
Cell adhesion molecules (CAMs) −1.58 0.002 0.027
Herpes simplex infection −1.60 0.002 0.022
Viral myocarditis −1.61 0.002 0.021
Melanoma −1.61 0.007 0.021
Bladder cancer −1.62 0.011 0.020
Galactose metabolism −1.63 0.011 0.019
Adipocytokine signaling pathway −1.63 0.002 0.018
Mineral absorption −1.63 0.008 0.018
Acute myeloid leukemia −1.64 0.011 0.017
Sphingolipid signaling pathway −1.65 < 0.001 0.015
MAPK signaling pathway −1.67 < 0.001 0.013
Pathways in cancer −1.67 < 0.001 0.013
Hepatitis C −1.68 < 0.001 0.012
Biosynthesis of amino acids −1.69 < 0.001 0.011
Protein digestion and absorption −1.72 < 0.001 0.008
Estrogen signaling pathway −1.72 < 0.001 0.008
Fc epsilon RI signaling pathway −1.74 < 0.001 0.007
Transcriptional misregulation in cancer −1.74 < 0.001 0.007
Natural killer cell mediated cytotoxicity −1.74 < 0.001 0.007
Glioma −1.74 < 0.001 0.007
Regulation of actin cytoskeleton −1.74 < 0.001 0.007
Bacterial invasion of epithelial cells −1.75 0.002 0.007
Cell cycle −1.76 < 0.001 0.006
Chemokine signaling pathway −1.76 < 0.001 0.006
Arginine and proline metabolism −1.77 < 0.001 0.005
Measles −1.77 < 0.001 0.006
Pancreatic cancer −1.78 < 0.001 0.005
Fc gamma R-mediated phagocytosis −1.79 < 0.001 0.005
HTLV-I infection −1.79 < 0.001 0.004
FoxO signaling pathway −1.80 < 0.001 0.004
Chronic myeloid leukemia −1.82 < 0.001 0.003
Prostate cancer −1.84 < 0.001 0.003
MicroRNAs in cancer −1.84 < 0.001 0.003
Hepatitis B −1.85 < 0.001 0.002
Salmonella infection −1.85 0.002 0.002
Protein processing in endoplasmic reticulum −1.87 < 0.001 0.002
VEGF signaling pathway −1.87 < 0.001 0.002
Epstein-Barr virus infection −1.87 < 0.001 0.002
Influenza A −1.88 < 0.001 0.002
Spliceosome −1.92 < 0.001 0.001
Phagosome −1.93 < 0.001 0.001
Tuberculosis −1.93 < 0.001 0.001
Chagas disease (American trypanosomiasis) −1.94 < 0.001 0.001
Hematopoietic cell lineage −1.96 < 0.001 0.001
Toll-like receptor signaling pathway −1.97 < 0.001 0.001
Jak-STAT signaling pathway −1.97 < 0.001 0.001
PI3K-Akt signaling pathway −1.97 < 0.001 0.001
Proteasome −1.98 < 0.001 0.001
Apoptosis −2.00 < 0.001 0.001
Rheumatoid arthritis −2.00 < 0.001 0.001
Amoebiasis −2.00 < 0.001 0.001
Antigen processing and presentation −2.00 < 0.001 0.001
Pertussis −2.05 < 0.001 < 0.001
Malaria −2.06 < 0.001 < 0.001
Staphylococcus aureus infection −2.06 < 0.001 < 0.001
Legionellosis −2.06 < 0.001 < 0.001
Osteoclast differentiation −2.07 < 0.001 < 0.001
B cell receptor signaling pathway −2.07 < 0.001 < 0.001
HIF-1 signaling pathway −2.08 < 0.001 < 0.001
Leishmaniasis −2.11 < 0.001 < 0.001
Proteoglycans in cancer −2.12 < 0.001 < 0.001
p53 signaling pathway −2.13 < 0.001 < 0.001
Leukocyte transendothelial migration −2.15 < 0.001 < 0.001
Complement and coagulation cascades −2.16 < 0.001 < 0.001
TNF signaling pathway −2.17 < 0.001 < 0.001
NF-kappa B signaling pathway −2.20 < 0.001 < 0.001
Toxoplasmosis −2.22 < 0.001 < 0.001
Cytokine-cytokine receptor interaction −2.23 < 0.001 < 0.001
Small cell lung cancer −2.27 < 0.001 < 0.001
Focal adhesion −2.29 < 0.001 < 0.001
ECM-receptor interaction −2.46 < 0.001 < 0.001
  1. Ephb2−/− and WT mice (n = 3) were subjected to 60 min MCAO followed by 48 h reperfusion. Total RNA was extracted from ipsilesional brain tissue and processed for DNA microarray analysis (GeneChip Mouse Gene 2.0 ST; Affymetrix, Santa Clara, CA, USA). The table lists all significantly UP and DOWN-regulated gene sets comparing Ephb2−/− versus WT matching the following criteria for selection: ≥1.5- or ≤ 1.5-fold regulation (log2-fold), p < 0.05 (ANOVA), FDR < 0.1. NES: normalized enrichment score; FDR: false discovery rate