Fig. 4
From: Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre
Occurrence of histone H3.3 K27M- (upper panel) and H3.3 G34-mutant gliomas in our cohort and the association with ATRX protein loss. Rarely, a biphasic pattern of ATRX expression is observed both in H3 K27M- and H3 G34R-mutant gliomas (light purple boxes). On one occasion we have identified H3F3A G34V mutation (asterisk in the age group 16–20 years). In another recurrent high-grade glioma, both primary and recurrent tumours were classified as H3 G34-mutant glioblastoma, although no mutations could be found in H3F3A, HIST1H3B and HIST1H3C genes (asterisk in the age group 36–40)