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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre

Fig. 2

a, the frequency of IDH mutations in our cohort (n = 1546). Blue, IDH1 mutations; orange and red, IDH2 mutations. The IDH1/IDH2 frequency in our cohort is slightly skewed toward rarer mutations, due to a proportion of referrals received specifically for sequencing studies. b, the frequency of IDH1 and IDH2 mutations and associated tumour types (n = 441 astrocytomas (of which 339 have IDH1-G395A); n = 363 oligodendrogliomas (of which 303 have IDH1-G395A)). Dark grey, astrocytomas; light grey, oligodendrogliomas. The mutations are sorted in descending order by overall frequency, excluding the most common IDH1-G395A mutation. The graph confirms the established association of certain mutations, in particular in the IDH2 gene, with oligodendroglial or astrocytic tumours

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