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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: White matter capillaries in vascular and neurodegenerative dementias

Fig. 3

Quantification of microvascular density a, Typical images of COL4 immunostained capillaries in the cortex and WM used to quantify densities. Scale bar represents 50 μm. b, Histogram showing microvascular densities in the WM and cortex in controls and different dementias. In the WM, mean microvascular density was consistently lower by ~ 49% compared to cortex in all controls and dementia groups (§P < 0.01). In different dementias, microvascular density in the WM was decreased by ~ 18% compared to ageing controls, particularly in PDD and Mixed dementia 1 group (P < 0.05), whereas PSD and PSND showed ~ 57% higher microvascular density (#P < 0.012 vs all disease and control groups other than PSND; P < 0.025 vs all disease groups other than ageing controls, Mixed 2 and PSD). In the cortex, dementia subjects showed ~ 20% lower vascular density compared with ageing controls, particularly in the PDD and Mixed dementia 1 group (*P < 0.05). Young control group showed less vascular density by ~ 23% compared with ageing controls (P < 0.01). c, Correlation of microvascular densities between COL4 and GLUT-1 immunostained areas in dementia subjects. Spearman’s correlation analysis revealed a strong positive correlation (rho = 0.79, P = 0.000)

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