Fig. 2

Tau pathologies in diverse tauopathies. Tau pathology in AD and PART comprise dystrophic neurites (a), axonal threads (b), pretangles (c) and NFTs (d). PSP is characterized by pretangles and threads (e), subcortical tangles (f), tufted astrocytes (g), and oligodendroglial coiled bodies (h). In CBD cases pretangles and threads (i), globose neuronal CBD-bodies (j), astrocytic plaques (k), and oligodendroglial coiled bodies (l) can be seen. AGD is characterized by 4R-tau positive neuronal dendritic grains (m), pretangles (n), granular/fuzzy astrocytes (o), and oligodendroglial coiled bodies (p). In GGT cases neuronal pretangles (q), spherical cytoplasmic inclusions (r), globular astroglial (s) and oligodendroglial (t) inclusions are detected. In Pick’s disease neuronal Pick bodies are frequent in the dentate gyrus (u) and show 3R immunoreactivity (v; here CA1 subregion is shown), furthermore, ramified astrocytes (w) and small globular oligodendroglial inclusions (x) can be noticed as well. Finally ARTAG comprises thorn shaped astrocytes and granular fuzzy astrocytes here demonstrated in the subependymal (y1), subpial (y2), perivascular (upper part of image 4) and white matter (lower part of image) (y3), and grey matter (y4) areas. All images show immunostaining for the AT8 antibody except (m) and (v) where immunostaining for 4R- and 3R-tau isoform, respectively, was performed. The bar in (a) represents 50 μm for a, e, f, g, h, l, m, t, u, v, y1, and y4; 35 μm for b, c, d, j, k, o, p, x; 30 μm for q and r; 40 μm for w and y2; 100 μm for i; 25 μm for s; and 150 μm for y3