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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Fig. 4

Significant behavioral abnormalities in TauA152T-AAV mice. a and b Behavior in open field analysis revealed an increase in total distance traveled (a F = 3.3, p = 0.04) and decrease in time spent breaking photobeams (b F = 10.51, p = 0.0002) in TauA152T-AAV compared to either GFP-AAV or TauP301L-AAV mice. c and d Exploratory behavior was also evaluated in elevated plus maze (EPM), which detected a significant increase in the time Tau-AAV mice spent in open arms (c F = 5.71, p = 0.006), as well as an increase in TauA152T-AAV mice in the ratio of time spent in open to closed arms (d F = 4, p = 0.026). e and f Cognitive function was assessed by fear conditioning, which demonstrated that TauA152T-AAV mice are significantly impaired in both context (e F = 5.62, p = 0.0067) and cued (f F = 7.835, p = 0.0012) versions of the task. g Rotarod was utilized to measure motor function, exposing significant motor impairment in TauA152T-AAV mice (Day 1: F = 5.18, p = 0.009; Day 3: F = 3.33, p = 0.04; Day 4: F = 4.4, p = 0.018). *p < 0.05, **p < 0.01, ***p < 0.001

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