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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Fig. 3

Increased astrogliosis in Tau-AAV mice. a-f Astrocytes and microglia were labeled with GFAP (a-c) and IBA1 (d-f), respectively, and representative images presented from the cortex. g GFAP immunoreactivity in the cortex was significantly increased in both TauP301L-AAV and TauA152T-AAV mice (F = 11.14, p = 0.0003). h GFAP is also significantly increased at the mRNA level in both Tau-AAV mouse models relative to GFP-AAV mice (F = 5.93, p = 0.0016). i Quantification of IBA1 immunolabeling in the cortex detected a significant increase only in TauP301L-AAV mice (F = 6.96, p = 0.0036). j RT-qPCR analysis revealed no significant differences of IBA1 (Aif1) mRNA levels between groups (F = 2.23, p = 0.12). Scale bar in (a) equal to 50 μm. *p < 0.05, **p < 0.005, ***p < 0.001

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