Fig. 1

Striking differences in the pattern of tau accumulation in P301L and A152T-expressing animals. a-f Representative low-power images comparing the distribution and intensity of CP13 and MC1 immunoreactivity in GFP-AAV (a and d), Tau^P301L-AAV (b and e), and Tau^A152T-AAV mice (c and f). g-v High-power images revealing differences in the deposition of CP13 and MC1-positive tau species between Tau^P301L-AAV (g-n) and Tau^A152T-AAV (o-v) mice in the cortex (g, k, o and s), hippocampus (h, l, p and t), midbrain (i, m, q and u) and brainstem (j, n, r and v). w Quantitative analysis of CP13 immunoreactivity was performed in cortex (t = 6.64, p < 0.0001); x hippocampus (t = 1.6, p = 0.12); y midbrain (t = 0.07, p = 0.95); and z brainstem (t = 7.36, p < 0.0001). Scale bar in (a-f) equals 2 mm; scale bar in (g-v) equals 20 μm. ****p < 0.0001