Fig. 6
From: Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth
Ex vivo effects of oxaliplatin and benztropine on the morphology of myelinated axons isolated from mouse sciatic nerves, using confocal microscopy. Representations of nodal length, diameter and volume, as functions of internodal diameter, of myelinated axons isolated from mice (n = 4 in each group) injected with vehicle (black closed circles, n = 137), oxaliplatin (red closed circles, n = 206), oxaliplatin plus benztropine (green closed circles, n = 150) or benztropine alone (blue closed circles, n = 160) for 6 weeks. The curves represent the linear (upper and middle panels) or non-linear (lower panels) fits of data points with R2 (correlation coefficients) between 0.441 and 0.877. In left panels, the arrows underline the effects of oxaliplatin