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Fig. 12 | Acta Neuropathologica Communications

Fig. 12

From: Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

Fig. 12

In vitro effects of oxaliplatin associated or not with benztropine on cell viability, GSH and ROS production. Viability was expressed as percent ± SEM versus cells in culture medium alone (100% viability) in CT26 cells (a) and N2a cells (b). GSH was measured using the monochlorobimane dye in CT26 cells (c) and N2a cells (d). ROS generation was measured using H2DCFDA fluorescent emission when converted to the highly fluorescent DCF in CT26 cells (e) and N2a cells (f). Data from at least 4 independent experiments have been pooled and were expressed as means ± SEM of triplicates. *p < 0.05, **p < 0.01 versus oxaliplatin

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