Fig. 1
From: Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth
In vivo effects of oxaliplatin and benztropine on acute oxaliplatin peripheral neuropathy. Evaluation of hyperalgesia required two 5-day cycles of daily oxaliplatin (3 mg/kg). Control mice received either oxaliplatin or vehicle alone. Cold hyperalgesia was evaluated using a cold plate set at + 2 °C. Data are expressed as means ± SEM of 7 different mice under each condition. *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle