TY - JOUR AU - Cerles, Olivier AU - Gonçalves, Tânia Cristina AU - Chouzenoux, Sandrine AU - Benoit, Evelyne AU - Schmitt, Alain AU - Bennett Saidu, Nathaniel Edward AU - Kavian, Niloufar AU - Chéreau, Christiane AU - Gobeaux, Camille AU - Weill, Bernard AU - Coriat, Romain AU - Nicco, Carole AU - Batteux, Frédéric PY - 2019 DA - 2019/01/18 TI - Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth JO - Acta Neuropathologica Communications SP - 9 VL - 7 IS - 1 AB - The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limited by peripheral neuropathy as a major side-effect. In a multiple sclerosis mouse model, benztropine, that also acts as an anti-histamine and a dopamine re-uptake inhibitor, induced the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination. We have evaluated whether benztropine can increase anti-tumoral efficacy of oxaliplatin, while preventing its neurotoxicity. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-019-0657-y DO - 10.1186/s40478-019-0657-y ID - Cerles2019 ER -