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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Fig. 7

– Summary of Findings of pTau Pathology in the rTg4510 Mouse Visual System. (a) Sagittal slice images from the Allen Brain Atlas (Image credit: Allen Institute) showing expression pattern of CaMKIIa in the adult mouse brain. Schematic of the layers of the neural retina, and immunohistochemical slice representative images of tau pathology (brown) in (b) wildtype and (c) rTg4510 mice, demonstrating the localisation of retinal and parenchymal tau pathology in the brain, overlaid with the geniculate and extra-geniculate visual pathways for contextualisation of the effect of tau pathology on the visual system

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