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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Fig. 5

– Tau Deposition and Neurodegeneration of Visual Pathways in the Brains of rTg4510 Mice. a Representative MR images of the brains of wildtype and rTg4510 mice displayed in the sagittal plane, with the visual cortex, hippocampus, thalamus and superior colliculus delineated. b Volumes of the cortex, hippocampus (Hipp), thalamus (Thal) and superior colliculus (SuCo) as ascertained through automated parcellation of MR images. Two-way ANOVA (n = 8, F1,3 = 307.7, p < 0.0001). c Wildtype and rTg4510 animal whole brain volumes extracted from MR images. Unpaired t-test (n = 8, p < 0.0001). d Regional volumes displayed in (b) normalised to whole brain volume displayed in (c). Two-way ANOVA (n = 8, F1,3 = 45.30, p < 0.0001). Representative PG-5 immunoreactivity in the (e) wildtype and (f) rTg4510 brain, with visual cortex (VisCortex), hippocampus (Hipp), thalamus (Thal), superior colliculus (SuCo) and optic tract (OpTr) delineated demonstrating forebrain localisation of pTau, and for extraction of immunoreactivity data presented in (g) pathology in the brain. Two-way ANOVA (n = 8, F1,4 = 404.1, p < 0.0001). Statistical significance indicated with asterisks: ** = p < 0.01; *** = p < 0.001

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