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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Fig. 4

Reduced Optic Nerve Volume in rTg4510 Mice Ascertained Through MRI. A Example images demonstrating the segmentation protocol used for volumetric analysis of the optic nerve from T2-weighted MR images. (a, b, c and d) Different horizontal levels of the 3D MR images, with the optic nerve highlighted in red. B Normalised (to total eye volume) volume of the optic nerve in wildtype and rTg4510 mice. Unpaired t-test (n = 8, p = 0.0375). Un-normalised and total eye volumes are shown in Additional file 1: Figure S4. C Correlation between MRI derived measures of optic nerve volume, and RGCL nuclear density derived from histology. Linear regression analysis (F1,9 = 53.66, p < 0.0001). (D) Difference in normalised T2 signal in the optic nerve of wildtype and rTg4510 mice. Unpaired t-test (n = 8, p = 0.0393). (E) Representative T2-weighted MR images of a cross-section of the optic nerve, with the optic nerve region pseudo colour scaled for signal intensity. Statistical significance indicated with asterisks: * = p < 0.05, **** = p < 0.0001

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