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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

Fig. 5

DRN D2Rs reduced striatal efflux of DA. a and b In vivo microdialysis of rAAV-D2Rs and rAAV-GFP animals in twenty-minute intervals following L-DOPA injection (12 mg/kg + 12 mg/kg Benserazide, s.c.). a rAAV-D2Rs animals showed significantly decreased DA efflux in the striatum 60–120 min following injection. b No changes in serotonin efflux in the striatum between vector groups was observed following L-DOPA injection. (* = p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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