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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

Fig. 4

D2Rs-injected animals do not develop severe AIMs with DA agonist treatment. Animals were treated three times each with apomorphine (a-c) quinpirole (d-f) or SKF-81297 (g-i). a-c rAAV-D2Rs-injected animals remained AIM resistant with 0.1 m/kg pan-DA agonist apomorphine treatment, while rAAV-GFP animals continued to exhibit dyskinetic behaviors. d-f 0.2 mg/kg quinpirole (D2 agonist) did not elicit AIMs in rAAV-D2Rs animals, where rAAV-GFP animals continued to exhibit moderate to severe AIMs. g-i rAAV-D2Rs began to show mild-to-moderate AIMs with 0.8 mg/kg of the D1 agonist SKF-81297 treatments, but remained significantly less severe than their rAAV-GFP counterparts. (* = p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001)

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