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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

Fig. 2

DRN D2Rs expression blocks LID development. a rAAV-D2Rs-injected animals did not develop LID over the course of 19 days of treatment with increasing doses of L-DOPA, where rAAV-GFP controls developed AIMs. b The total AIM score for each rating session was significantly different between groups starting on treatment day 8 with 8 m/kg L-DOPA. D2Rs animals remained LID-. c-f AIM scores from days 12, 15, 17, and 19 showing LID severity in 25 min intervals. GFP animals displayed a typical dyskinetic response to chronic L-DOPA treatment, with increasing AIM severity seen at higher doses. The peak-dose severity (AIM score at 75 min-post L-DOPA injection) was significantly higher in GFP animals than D2Rs animals in the last 4 days of the L-DOPA paradigm. (* = p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001)

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