Table 2 Distribution of neuronal storage material and PAS-positive granules in the central nervous system. Screening for neuronal inclusions was performed on sections stained with cresyl violet luxol fast blue (LFB) and sudan black (SB) or under ultraviolet light excitation for emission of autofluorescence (AF)
Region | Neuronal storage material | PAS + granules | ||
|---|---|---|---|---|
LFB/SB | AF | |||
Cerebrum | ||||
Basal ganglia | Neocortex I – IV | – | ++ | ++ |
Neocortex V - VI | +++ | +++ | ++ | |
Nucleus caudatus | (+) | + | – | |
Putamen | – | ++ | (+) | |
Claustrum | +++ | +++ | – | |
Thalamus | ++ | +++ | – | |
Hippocampus | CA 1 | ++ | +++ | + |
CA 2–4 | + | ++ | + | |
Corpus geniculatum laterale | +++ | +++ | n. a. | |
Cerebellum | Cortex | |||
Purkinje cells | – | – | – | |
Granule cells | – | – | – | |
Subcortical white matter | – | – | +++ | |
Nucleus dentatus | (+) | ++ | +++ | |
Brain stem | ||||
Mesencephalon | Substantia nigra | – | (+) | ++ |
Nucleus oculomotorius | – | (+) | n. a. | |
Pons | Pontine nuclei | (+) | + | +++ |
Raphe nuclei | (+) | + | +++ | |
Medulla oblongata | Olivary nuclei | +++ | +++ | (+) |
Nucleus nervus vagus | +++ | +++ | – | |
Nucleus nervus hypoglossus | – | ++ | – | |