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Table 2 The difference in average axon diameter, midsagittal area, and myelin thickness in five CC segments in autistic (A) and control (C) subjects

From: Deficit of corpus callosum axons, reduced axon diameter and decreased area are markers of abnormal development of interhemispheric connections in autistic subjects

Parameter

Group

CC Segment

S I

S II

S III

S IV

S V

Axon diameter (μm) (SE)

C

0.869 (0.025)

0.945 (0.026)

1.108 (0.036)

1.120 (0.058)

1.075 (0.043)

A

0.772 (0.016)

0.836 (0.020)

0.837 (0.059)

0.858 (0.061)

0.768 (0.046)

p <

0.005**

0.004**

0.001***

0.010**

0.0002***

Difference

−11.2%

−11.5%

−24.4%

−23.4%

−28.6%

Axon area (μm2) (SE)

C

0.613 (0.042)

0.739 (0.039)

1.075 (0.068)

1.157 (0.117)

0.968 (0.086)

A

0.462 (0.024)

0.543 (0.032)

0.594 (0.071)

0.620 (0.081)

0.469 (0.056)

p <

0.006**

0.001***

0.0002***

0.005**

0.0002***

Difference

−24.6%

−26.5%

−44.8%

−46.9%

−51.6%

Myelin thickness (μm) (SE)

C

0.149 (0.006)

0.153 (0.006)

0.162 (0.005)

0.163 (0.008)

0.157 (0.004)

A

0.139 (0.003)

0.149 (0.003)

0.142 (0.011)

0.145 (0.007)

0.132 (0.008)

p <

0.197

0.538

0.092

0.141

0.018*

Difference

ns

ns

ns

ns

−15.8%

  1. CC Corpus callosum, SE standard error, ns not significant
  2. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001