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Table 2 The difference in average axon diameter, midsagittal area, and myelin thickness in five CC segments in autistic (A) and control (C) subjects

From: Deficit of corpus callosum axons, reduced axon diameter and decreased area are markers of abnormal development of interhemispheric connections in autistic subjects

Parameter Group CC Segment
S I S II S III S IV S V
Axon diameter (μm) (SE) C 0.869 (0.025) 0.945 (0.026) 1.108 (0.036) 1.120 (0.058) 1.075 (0.043)
A 0.772 (0.016) 0.836 (0.020) 0.837 (0.059) 0.858 (0.061) 0.768 (0.046)
p < 0.005** 0.004** 0.001*** 0.010** 0.0002***
Difference −11.2% −11.5% −24.4% −23.4% −28.6%
Axon area (μm2) (SE) C 0.613 (0.042) 0.739 (0.039) 1.075 (0.068) 1.157 (0.117) 0.968 (0.086)
A 0.462 (0.024) 0.543 (0.032) 0.594 (0.071) 0.620 (0.081) 0.469 (0.056)
p < 0.006** 0.001*** 0.0002*** 0.005** 0.0002***
Difference −24.6% −26.5% −44.8% −46.9% −51.6%
Myelin thickness (μm) (SE) C 0.149 (0.006) 0.153 (0.006) 0.162 (0.005) 0.163 (0.008) 0.157 (0.004)
A 0.139 (0.003) 0.149 (0.003) 0.142 (0.011) 0.145 (0.007) 0.132 (0.008)
p < 0.197 0.538 0.092 0.141 0.018*
Difference ns ns ns ns −15.8%
  1. CC Corpus callosum, SE standard error, ns not significant
  2. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001
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Acta Neuropathologica Communications

ISSN: 2051-5960

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