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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Fig. 7

Overexpression of Miro1 in MSCs boosts NSC survival and enhances mitochondrial transfer to injured NSCs. Representative confocal images of Neuronal stem cells (NSCs) stained with cell tracker blue (CTB) and subsequently co-cultured for 17 h with mesenchymal stem cells (MSC) transfected with mito-mcherry (a-d) and miro1-GFP (b, d) to label the MSC-derived mitochondria. Neuronal stem cells (NSCs) were treated with 1 μM cisplatin for 8 h and then co-cultured for 17 h with mesenchymal stem cells (MSCs) overexpressing Miro1 GTPase (MSC Miro1), MSCs transfected with empty vector (MSC Ctl), or without MSCs. Mitochondrial transfer (e) and survival (f) were assessed as in Fig. 6. Data were analyzed by two-way ANOVA followed by Bonferroni’s post-hoc test. ** P < 0.01; * P < 0.05

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