Fig. 3
From: Co-occurrence of chronic traumatic encephalopathy and prion disease
Lesion profiles of CTE, and matched sCJD controls. The lesion profiles from each of the prion-positive CTE cases matched that of the respective sCJD control. a: CTE MV1-2C (case 1) and sCJDMV1-2C. The hippocampus from the CTE case was unavailable for lesion rating. b: CTE MV2K-C (case 2) and sCJDMV2K-C. c: CTE MM1 (case 3) and sCJDMM1. Lesion profiles were generated using the combined scores (mean ± SEM) for spongiform degeneration (SD) and gliosis for each of the 10 brain regions examined. SD was scored on a 0 to 4 scale (0, not detectable; 1, mild; 2, moderate; 3, severe). Gliosis was scored on a 0 to 4 scale (0, not detectable; 1, scattered activated nuclei; 2, moderate activated nuclei; 3, some reactive astrocytes with visible perikaryon; 4, mostly reactive astrocytes with visible perikaryon). FC: frontal cortex (cx); TC: temporal cx; PC: parietal cx; OC: occipital cx; HI: hippocampus (CA1 region); EC: entorhinal cx; BG: basal ganglia; TH: thalamus, SN: substantia nigra; CE: cerebellum