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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Co-occurrence of chronic traumatic encephalopathy and prion disease

Fig. 2

Tau and PrP immunostaining in CTE Cases 1–3. a: Perivascular tau pathology consisting of p-tau immunoreactive neurofibrillary tangles (NFT), dotlike neurites and immunoreactive astrocytes distributed in an irregular pattern in deep cortical regions. b: NFT preferentially involving the superficial layers (layers II-III); inset: tau-positive dystrophic neurites associated with an Aβ plaque. c-e (p-tau and PrP double immunostaining): Overall, p-tau neurofibrillary pathology (brown in c and e, cyan in d) predominated in the superficial layers of the cerebral cortex while PrP pathology (cyan in c and e, brown in d) preferential affected deeper layers; e: arrow: perivascular p-tau pathology. f: P-tau immunoreactive “dot-like” structures (arrow); arrowhead: neuropil thread. g: Perivascular p- tau pathology with thorn-shaped astrocytes; arrowheads: blood vessels. h: P-tau immunoreactive astrocytes. i and j (p-tau and PrP double immunostaining): p-tau neurofibrillary pathology (brown in i and cyan in j) preferentially affecting the superficial layers of the cerebral cortex while PrP pathology (cyan in i, brown in j) predominated in deep layers; i: arrowhead: perivascular p-tau pathology. k and l: Perivascular p-tau NFT and dot-like neurites in a deep cortical region (k); subpial perivascular thorn-shaped astrocytes and NFT (j); l, inset: a NFT. Abs 3F4 (to PrP) and AT8 (to tau). Scale bar in insets: 25 μm (b) and 20 μm (l)

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