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Table 1 Characteristics of included study subjects

From: Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer’s disease and cerebrovascular disease pathologies

Characteristic All included subjects
(n = 929)
No TDP-43 pathology
(n = 637)
TDP-43 pathology at least one regiona
(n = 292)
P-valueb Excluded subjectsc
(n = 563)
P-valued
Age at death, mean ± SD 83.1 ± 8.7 82.4 ± 8.8 84.8 ± 8.5 < 0.001 84.4 ± 9.0 0.012
Gender, n (%)
 Male 481 (51.8) 341 (53.5) 140 (47.9) 0.13 287 (51.0) 0.81
 Female 448 (48.2) 296 (46.5) 152 (52.1) 276 (49.0)
Education (years), mean ± SD 15.5 ± 3.1 15.5 ± 3.1 15.5 ± 3.2 0.95 15.2 ± 3.3 0.10
APOE, n (%)
 −/− 370 (49.0) 275 (51.6) 95 (42.8) 0.063 229 (52.8) 0.43
 −/ε4 309 (40.9) 210 (39.4) 99 (44.6) 162 (37.3)
 ε4/ε4 76 (10.1) 48 (9.0) 28 (12.6) 43 (9.9)
Diabetes, n (%)
 Recent/remote 91 (15.5) 66 (15.6) 25 (15.2) 1 56 (13.2) 0.35
 Absent 495 (84.5) 356 (84.4) 139 (84.8) 368 (86.8)
Hypertension, n (%)
 Recent/remote 375 (64.3) 270 (64.1) 151 (64.8) 0.95 281 (67.9) 0.27
 Absent 208 (35.7) 105 (35.9) 57 (35.2) 133 (32.1)
Hypercholesterolemia, n (%)
 Recent/remote 411 (63.7) 300 (63.6) 111 (64.2) 0.96 297 (66.4) 0.39
 Absent 234 (36.3) 172 (36.4) 62 (35.8) 150 (33.6)
Thyroid disease present, n (%)
 Yes 70 (24.4) 48 (24.5) 22 (24.2) 1 31 (22.5) 0.75
 No 217 (75.6) 148 (75.5) 69 (75.8) 107 (77.5)
  1. aTDP-43 pathology at least one of the five regions: spinal cord, amygdala, hippocampus, EC/inferior TCTX, and frontal neocortex
  2. bThe p-values were computed for the associations with TDP-43 inclusions statuses
  3. cSubjects excluded due to missing TDP-43 data in all regions or other TDP-43 antibody used
  4. dThe p-values were computed for the associations between all included subjects and the subjects with no data on TDP-43 inclusions
  5. SD standard deviation
  6. Bold p-value represents the statistical significance