Table 1 Characteristics of included study subjects
Characteristic | All included subjects (n = 929) | No TDP-43 pathology (n = 637) | TDP-43 pathology at least one regiona (n = 292) | P-valueb | Excluded subjectsc (n = 563) | P-valued |
|---|---|---|---|---|---|---|
Age at death, mean ± SD | 83.1 ± 8.7 | 82.4 ± 8.8 | 84.8 ± 8.5 | < 0.001 | 84.4 ± 9.0 | 0.012 |
Gender, n (%) | ||||||
Male | 481 (51.8) | 341 (53.5) | 140 (47.9) | 0.13 | 287 (51.0) | 0.81 |
Female | 448 (48.2) | 296 (46.5) | 152 (52.1) | 276 (49.0) | ||
Education (years), mean ± SD | 15.5 ± 3.1 | 15.5 ± 3.1 | 15.5 ± 3.2 | 0.95 | 15.2 ± 3.3 | 0.10 |
APOE, n (%) | ||||||
−/− | 370 (49.0) | 275 (51.6) | 95 (42.8) | 0.063 | 229 (52.8) | 0.43 |
−/ε4 | 309 (40.9) | 210 (39.4) | 99 (44.6) | 162 (37.3) | ||
ε4/ε4 | 76 (10.1) | 48 (9.0) | 28 (12.6) | 43 (9.9) | ||
Diabetes, n (%) | ||||||
Recent/remote | 91 (15.5) | 66 (15.6) | 25 (15.2) | 1 | 56 (13.2) | 0.35 |
Absent | 495 (84.5) | 356 (84.4) | 139 (84.8) | 368 (86.8) | ||
Hypertension, n (%) | ||||||
Recent/remote | 375 (64.3) | 270 (64.1) | 151 (64.8) | 0.95 | 281 (67.9) | 0.27 |
Absent | 208 (35.7) | 105 (35.9) | 57 (35.2) | 133 (32.1) | ||
Hypercholesterolemia, n (%) | ||||||
Recent/remote | 411 (63.7) | 300 (63.6) | 111 (64.2) | 0.96 | 297 (66.4) | 0.39 |
Absent | 234 (36.3) | 172 (36.4) | 62 (35.8) | 150 (33.6) | ||
Thyroid disease present, n (%) | ||||||
Yes | 70 (24.4) | 48 (24.5) | 22 (24.2) | 1 | 31 (22.5) | 0.75 |
No | 217 (75.6) | 148 (75.5) | 69 (75.8) | 107 (77.5) | ||