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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1

Fig. 4

ATP requires β-arrestins to suppress SC proliferation. (a) Schematic representation of known G-protein-dependent calcium signaling and delayed G-protein-independent arrestin signaling. (b) Growth with PP2A inhibitors okadaic acid or Forstrecin rescue the anti-proliferative effects of ATPγS. (c) Growth suppression of WT mSCs by ATP or ATPγS was also rescued by okadaic acid. (d) iHSCs treated with shRNA to PPP2CA show reduced growth suppression in response to ATPγS

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