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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1

Fig. 1

Nerve conduction controls Schwann cell quiescence in adult nerve. (a) Nerve electrical conduction correlates with axonal release of ATP. TTX and BupOH inhibit nerve conduction-mediated ATP release. (b) At Day 5, TTX-blocked WT adult sciatic nerves contained increased proliferating (Ki67+) cells (n = 7/group, p < 0.001). (c) No significant increase in Ki67+ cells was observed at 24 h of BupOH treatment (ns; n = 5/group), while (d) at 5 days of BupOH administration Ki67+ cells increased (n = 6/group, p < 0.001). (e) Cross sections of BupOH and TTX treated sciatic nerves were labeled with anti-myelin basic protein (MBP; green) and Ki67 (red). Cell nuclei are blue. Some Ki67+ nuclei are adjacent to MBP+ myelin sheaths (white arrow), while others were not (arrowheads)

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